文摘

治疗酮症和生酮饮食的广泛应用领域:酮酯应用与临床的更新

作者(年代):拉斐尔Pilla

最近表明,营养酮症是有效对抗癫痫疾病和各种急性/慢性神经系统疾病。生理上,葡萄糖是主要的代谢燃料电池。然而,许多神经退行性疾病相关与葡萄糖运输/代谢和线粒体功能障碍,如老年痴呆症? s /帕金森? ? ?疾病,一般癫痫症和创伤性脑损伤。酮体和三羧酸循环中间体代表替代燃料对大脑和可以绕过率——限制步骤与受损的神经元葡萄糖代谢有关。因此,治疗性酮症可以被认为是通过提供替代能源基质代谢疗法。据估计,大脑总能量的60%以上来自酮葡萄糖时可用性是有限的。事实上,经过长时间的禁食或生酮饮食(KD),身体利用能量从游离脂肪酸从脂肪组织释放(远期运费协议)。因为大脑是无法从远期运费协议中获得重大能源,肝酮生成将远期运费协议转化为酮bodies-hydroxybutyrate (BHB)和乙酰乙酸盐(中航商用飞机有限公司)的比例而中航商用飞机有限公司自发脱羧基丙酮。大量的酮体堆积在血液通过这种机制。这是正常的生理状态酮症,可以治疗。 Ketone bodies are transported across the blood-brain barrier by monocarboxylic acid transporters to fuel brain function. Starvation or nutritional ketosis is an essential survival mechanism that ensures metabolic flexibility during prolonged fasting or lack of carbohydrate ingestion. Therapeutic ketosis leads to metabolic adaptations that may improve brain metabolism, restore mitochondrial ATP production, decrease reactive oxygen species production, reduce inflammation, and increase neurotrophic factors??? function. It has been shown that KD mimics the effects of fasting and the lack of glucose/insulin signaling, promoting a metabolic shift towards fatty acid utilization. In this work, the author reports a number of successful case reports treated through metabolic ketosis.