摘要

孕激素对老年痴呆症大鼠的影响

作者(年代):Banan Khojasteh Seeyed Mahdi, Mozafari Maryam和Hatami Homeira

背景:阿尔茨海默病(AD)是一种进行性神经退行性疾病和异质性精神疾病，其特征是年龄依赖性记忆丧失和多种认知功能损害。氧化应激是阿尔茨海默病和记忆障碍发病机制中起有效作用的因素之一。氧化应激的发生是由于氧化剂和抗氧化剂水平的不平衡。在AD大脑中，过氧化氢酶等预防性抗氧化剂水平下降;MDA和SOD酶也被证明对神经存活和神经元抗氧化损伤的保护至关重要。STZ经脑室内注射(i.c.v)可在大脑中产生氧化应激和认知障碍，可能导致散发性阿尔茨海默病。黄体酮有可能通过减少氧化应激，从神经发生到改善记忆。除了观察到PROG及其代谢产物发挥与中枢神经系统生理相关的功能外;它们也是中枢神经系统的保护剂。本研究旨在通过减少自由基的机制来评估孕激素对阿尔茨海默病的潜在影响。 Material and method: 48 male rats after cannulating, randomly divided into 8 groups (n=8) including: 1. Control group 2. Shame group (sesame oil). 3. Groups of Alzheimer's disease (recipient of streptozotocin (3mg / kg)) 4-6. STZ plus progestrone (2, 1.5, 0.5μg / kg). All groups except the control were cannulated bilaterally ventricular area by stereotaxic device. Alzheimer's model was induced by intracerebroventricularly injection of streptozotocin (3mg/kg). After Indus Alzheimer Progesterone injected through the cannula and control groups received sesame oil. Characteristic of learning and spatial memory was assessed using Morris Water Maze for 5 consecutive days. At the end, the level of FRAP were measured in rat’s blood. Results: Administration progesterone significantly improved spatial memory in experimental models of Alzheimer's rats (P<0.001). FRAP amount in All dose of progesterone showed a significant reduction compared to the AD animals (P<0.001). Conclusion: It seems that pretreatment with progesterone by reduces oxidative stress and reduce the production of free radicals and therefore reduce the damage induced Alzheimer's disease and has the ability to prevent the impairment in the experimental models of Alzheimer's rats