文摘

一些新奇的喹啉的合成通过克诺尔吡唑和吡唑啉酮衍生品和喹啉合成和评估他们的抗菌活动

作者(年代):诉r·沙j . n . Godhasra m . c . Patel和n n Kansagara

Pyrazolones (5a-l) were synthesized by the reaction of -keto ester and hydrazines in the presence of catalytic amount of acetic acid. Formation of 2-quinolones (6a-l) took place from -ketoester and arylamines (3a-l) above 100°C. The intermediate anilide undergoes cyclization by dehydration with concentrated sulfuric acid. All the prepared compounds were characterized by their spectral (IR, NMR, Mass) data and screened for their antimicrobial activity. Reaction of hydrazine or substituted hydrazine with 1, 3-dicarbonyl compounds provided the pyrazolone ring system