文摘

类似的降血脂药和抗氧化性能的¯§——一个¯¤-tocotrienols隔绝不同水稻品种实验诱导Hyperlipidemic老鼠

作者(年代):穆罕默德·Minhajuddin Jahangir伊克巴尔扎发h .乞讨

降血脂药-抗氧化的性质-丰富的分数(基金会),特别是g -和d-tocotrienols,隔离不同水稻品种没有被研究过,对我们的知识。当前研究的目的是评估降血脂药和抗氧化效果的g - d-tocotrienols,分离出不同品种的米糠,在实验诱导hyperlipidemic老鼠。高脂血症是由喂养诱导的粥样硬化饮食(5%氢化脂肪,0.5%胆酸和1%胆固醇)三个星期。最后三个星期,四个老鼠在正常和hyperlipidemic集团是牺牲了零水平的各种参数来确定时间。有大约3倍血浆甘油三酯水平增加hyperlipidemic老鼠比正常控制。血浆总胆固醇水平增加了2.5倍,这主要是由于增加5倍的低密度脂蛋白胆固醇的水平,只有一个小增加高密度脂蛋白胆固醇。有超过75%的减少hyperlipidemic动物β-还原酶的活性,可能由于反馈抑制。硫代巴比土酸的形成活性物质(TBARS)和共轭双烯增长了92%增长了72%。高脂血症的感应三周后,大鼠补充2.83毫克,8.23毫克和3.02毫克的纯化扶轮基金会与印度香米(长粒),mansuri粮食(中),或sarju-52(短纹),分别为一个星期。扶轮基金会的剂量计算基于g - 8毫克当量浓度和d-tocotrienols出现在精炼米糠油年级无关)。 TRF supplementation from different rice cultivars equally decreased the lipid parameters in the hyperlipidemic rats. HMG-CoA reductase activity, which was increased after the withdrawal of atherogenic diet, remained significantly decreased during the TRF treatment in all the treatment groups. TRF from different cultivars decreased the levels of TBARS and conjugated dienes significantly. These results suggest that g- and d-tocotrienols in the TRF isolated from different rice cultivars equally modulated various physiological functions including atherogenic lipid profiles and antioxidants in hypercholesterolemia.