文摘

黄连木乳香树l和气道平滑肌

作者(年代):Badreddine Fehri, jean - marc Aiache

黄连木的影响乳香树l .叶提取物(水、30%乙醇和70%乙醇)研究了老鼠的孤立的气管。黄连木乳香树l .提取物诱导放松对基底的语气和气管订婚。在老鼠孤立气管由乙酰胆碱10-3M婚约,黄连木lenticus l .叶提取物(水、30%乙醇和70%乙醇)诱导放松。EC50值70%乙醇、30%乙醇和水分别extractswere: 1.00.10-3±0.11 (n = 15), 1.71.10-3±0.09 (n = 8)和1.75.10-3±0.12克/毫升(n = 12)。放松对黄连木lentiscusL。70%乙醇提取为182.14±17.52% (n = 15)应对茶碱的3.10 - 3米。阿托品、普萘洛尔、酚妥拉明(10-7M)和吲哚美辛(10-6M) notmodifyPistacia乳香树l .诱导放松。Forskolin (10-6M) andmethylene蓝色(3.10 - 5米)分别会得罪了黄连木乳香树l .放松。研究提取4(10 - 6打败g / ml)并不影响茶碱,IBMX (3-isobutyl-1-methylxantine、硝苯地平、双嘧达莫,rolipramand siguazodamconcentration-response曲线但以剂量依赖的方式造成左移的卡托普利,钠nitroprussiate, 8 phenyltheophylline enprofylline。此外,提取诱发总逆转zaprinast-induced放松。 On precontracted rat trachea, adenosine induced contractile response and predominant relaxation. Pistacia lentiscus L. blocked adenosine contractile response and potentiated the purine nucleosie relaxation. It is suggested that the recorded relaxation induced by the studied drug involves several mechanisms of action including an inhibition of angiotensin I converting enzyme (ACE), an interaction with phosphodiesterase (PDE) V and an interaction at adenosine receptors level.