文摘

铁(III)催化Biginelli-like三个组件Cyclocondensation反应:高效合成新型5-Substituted 3 4-Dihydropyrimidin-2 (1 h)的

作者(年代):Nainesh n . Kansagara贾格迪什n . Godhasra Mahesh c·帕特尔和病毒r·沙阿

The Biginelli reaction, a one-pot condensation of aryl aldehyde, urea and -dicarbonyl compounds are efficiently catalyzed by iron (III) in acetonitrile to afford the corresponding novel 5- substituted 3, 4-dihydropyrimidin-2-(1H)-ones (2a–i) in high yields. The first Biginelli-like reactions of urea, aryl aldehydes and ketones were furnished important to synthesize new 3, 4-dihydropyrimidin-2- (1H)-ones derivatives suitable for further study. The newly synthesized compounds have been characterized by elemental analysis, IR, 1H NMR and MS spectral data. Some of these compounds showed potential antimicrobial activity.