摘要
基于miRNA诊断的微流体混合器的改进混合效率和缩放
作者(年代):Salim B, Arumugham K, Madhu G和Athira MV随着基于microrna (miRNA)生物标志物的疾病检测的出现,诊断和预后发生了革命性的变化。目前,许多研究的重点是设计和开发适合芯片实验室型诊断设备配置的微流控平台。本文设计了一种用于杂交靶miRNA的微流控纳米级流体混合器及其共轭探针,并对其性能进行了评价。在微流体通道中,流体流动是层流的,混合可以通过对流和扩散的方式发生。微通道中低雷诺数流动的控制方程在连续性方程和经典的Navier-Stokes方程的基础上增加了附加项,以考虑传质效应。此外,由于连续性方程、动量方程和能量方程中存在扩散分量,因此需要作为联立方程求解。Comsol Multiphysics 5.2a能够对这种流进行建模,并用于混合器的模拟。用于靶miRNA检测的原理是基于淬灭探针杂交后的荧光检测。在本研究中,通过增加机械结构来增加流体之间的相互作用,提高对流对混合过程的贡献,从而设计了更好的混合器。设计并制作了三种具有柱状结构的微流体混合器,以不同方式改变流动模式,以增强杂交对目标miRNA的检测,并与普通T型混合器进行了性能比较。 The design parameter of interest is the length of the channel which is sufficient for hybridization for a chosen flow rate. A study is performed to assess the mixing effectiveness at various lengths for a channel of fixed length. The major conclusion is that the mixer with zig-zag structure provides the best mixing among the three structures tested, where convection and diffusion were both contributing to mixing, with the convective component significantly enhanced compared to the plain T mixer. The fabricated devices were Y type for simplicity.
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