文摘

同型半胱氨酸水平、氧化状态和止血反应在大鼠慢性压力

作者(年代):Scoppa HG,法瑞斯Binotti S, M, Stagnoli, Echegaray N, N和Niebylski Bensi

多项研究表明,同型半胱氨酸(Hcy)水平受饮食影响因素和糖等因素的压力。增加总血浆Hcy浓度被认为是心血管疾病的一个独立危险因素。已经证明了循环的Hcy水平升高导致止血法通过改变血管内皮功能的变化,改变其表面的性质从pro-coagulant抗凝。另一方面,它已经表明,心理社会应激增加pro-thrombotic的原生质的水平因素。本研究的目的是评估Hcy水平和氧化状态的止血剂反应在大鼠长期固定的压力。两组雄性Wistar鼠被认为:对照组(C)和固定压力组织(IMO)。老鼠强调2 h(从10.00点到12.00点)14天。在14天之后立即过去的国际海事组织,动物被斩首。血液采集标本,凝血时间(CT)、局部血栓形成质时间(APTT)、血小板计数、纤维蛋白原,Hcy、硫代巴比土酸活性物质(TBARs),抗氧化能力的等离子体(收紧),亚硝酸盐(NOx)和皮质甾酮水平测定。相关测试与Hcy CT、氮氧化物和皮质甾酮。 An increase in plasma corticosterone, platelet count, and fibrinogen and homocysteine levels in response to stress was observed. FRAP, CT,APTT, and NOx serum values were lower in stressed animals while no significant differences in TBARs plasma concentration to IMO were found. Positive correlation was found between Hcy and corticosterone levels and negative correlation for Hcy and NOx and Hcy and CT was observed. IMO chronic stress modifies the hemostatic response leading to a pro-thrombotic state with an increase of platelets, fibrinogen and Hcy. The rise in Hcy appears to depend on corticosterone levels. Increased Hcy decrease NO bioavailability, which would promote platelet adhesion to endothelial cells favoring the formation of blood clots in response to chronic stress situations, which would increase the risk of thromboembolic events in situations of chronic stress.