文摘

adapalene估计通过权力平等主义的高效液相色谱法在药物凝胶配方

作者(年代):M。Mudasir, N。Tabassum, J。阿里,R.Jan

一个简单的、有选择性的、精确的和stability-indicating权力平等主义的高性能的色谱分析方法adapalene制药(凝胶)配方中。流动相由乙腈(ACN),四氢呋喃(四氢呋喃)和磷酸盐缓冲剂(PB) (ph值- 2.5;0.01米)的比率分别30:40:30。Thismobile阶段给予足够的结果被发现峰的形状,对称,切线和尾矿。保留时间(RT) adapalene被发现2.4运行时的5分钟。样品受到酸、碱水解、氧化、热、湿度、光降解。整个分析进行的波长272 nm。标定块的线性回归分析数据显示良好的线性关系,r2 = 0.9995对峰面积的浓度范围14-26iAg / ml。相关系数的平均值;斜率和interceptwere 0.9995、9060.51和1282。精度的方法验证、特异性、复苏和健壮性,按照我的指导方针。乐动KENO快乐彩 The drug undergoes degradation under basic (alkaline) conditions. This indicates that the drug is susceptible to base hydrolysis. Statistical analysis proves that the method is reproducible, selective and accurate for the estimation of said drug. As the method could effectively separate the drug from its degradation product, it can be employed as a stability-indicating one.