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利尿活性的大戟属植物cotinifolia提取物在成人纯种白化病老鼠:草使用本地管理的心血管疾病

作者(年代):帕梅拉Nawaggi,戈弗雷年代。Bbosa,马尔科姆·卡乌马,阿洛伊修斯Lubega

利尿剂是常用心血管疾病如高血压的管理。研究调查的利尿剂活动乙醚和乙醇提取物的大肠cotinifolia叶在成人纯种白化大鼠与呋喃苯胺酸和生理盐水分别为积极的和消极的控制。四组每6个健康的成年老鼠的。组我给5毫升生理盐水intragastrically。第二组被给予5毫升10毫克/公斤b.wt。呋喃苯胺酸。第三组被给予5毫升b.wt 400毫克/公斤。乙醇提取。第四组是400毫克/公斤b.wt 5毫升。醚提取物。 The mean hourly total cumulative total urine output for each group was determined for 5 hours and was used to calculate the diuretic activity of both extracts. The pH and specific gravity of the urine output were determined using the pH urinalysis strips and the urine electrolytes; creatinine and urea/BUN levelswere determined using COBAS INTEGRA 400 plus automated analyzer. Ether extract had the highest mean hourly cumulative total urine output of 17.80±0.36 ml with diuretic activity of 1.60 as compared to the 11.00±0.66 ml of furosemide after 5 hours and difference was statistically significant (pï‚£0.05) at all the time intervals of urine collection. Ether extract group had a pH of 7.0±0.36, specific gravity of 1.02±0.01, [K+] of 132.00±3.61 mMol/l, creatinine of 2158.00±5.29 µMol/l and urea/BUNof 484.40±6.38 mMol/l that were slightly higher as compared to that of furosemide. The [Na+]was 126.00±4.01 mMol/l and that of chloride [Cl-] was 144.00±3.10 mMol/l slightly lower as compared to furosemide and the difference was statistically significant (pï‚£0.05). The results conclude that E. cotinifolia leaves contains compounds with diuretic activity and hence its folklore use as a diuretic in the management of cardiovascular diseases like hypertension is justified.