文摘

撒哈拉以南非洲地区出生剂量疫苗接种覆盖率和及时性:系统回顾和荟萃分析

作者(年代):Bassoum Oumar

根据每个国家的流行病学背景下,三种疫苗是由世界卫生组织(世卫组织)推荐管理尽快出生后(出生疫苗);BCG、零剂量的口服脊髓灰质炎疫苗(OPV0),和出生剂量的乙肝疫苗(HepB-BD)。出生后立即及时管理这些疫苗可能带来重大挑战在撒哈拉以南非洲,大约一半的生育时卫生设施以外的地方。因此,我们进行了一项系统回顾和荟萃分析来估计这些疫苗的覆盖率在特定时间在非洲撒哈拉沙漠以南地区的新生儿。方法:我们搜索PubMed、Embase CINAHL,和网络发表的科学研究在撒哈拉以南非洲和3月31日,2017年,提供了一个生产疫苗的覆盖率出生后28天内任何特定的时间点。两个独立调查人员筛选合格的标题和摘要和提取数据全文。本研究在普洛斯彼罗注册(CRD42017071269)。结果:识别出的7283篇文章,我们终于包括31个荟萃分析研究204111名婴儿。在出生后0 - 1天汇集覆盖率是14.2%(95%置信区间:10.1—-18.9)BCG和HepB-BD 1.3% (0.0 - 4.5)。没有数据可供OPV0天0 - 1。 The coverage at day 28 was 71.7% (63.7-79.2) for BCG, 60.8% (45.8-74.7) for HepB-BD, and 76.1% (67.1-84.0) for OPV0. No significant difference in the vaccine coverage was observed between infants born in healthcare facilities and those born outside facilities. Conclusions: The rates of vaccine coverage immediately after birth were very low for BCG and HepB-BD, and no data for OPV0. We need additional data to better define barriers and facilitators for the timely administration of the birth vaccines in sub-Saharan Africa, since the delay in its provision may increase the burden of these vaccine-preventable diseases.