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长期饮酒会影响免疫血细胞计数在艾滋病毒/艾滋病患者而/ 3 tc /一步法药物疗程9个月随访期间

作者(年代):戈弗雷。Bbosa,大卫B。Kyegombe威廉·W。Anokbonggo,阿波罗穆吉沙,贾斯帕Ogwal-Okeng

全球慢性饮酒是一种常见的问题包括艾滋病毒/艾滋病患者抗病毒治疗。乙醇及其代谢产物减少造血作用,也影响免疫激活HPA轴释放皮质醇血细胞的生产。研究确定影响慢性乙醇使用免疫血液细胞计数在艾滋病毒/艾滋病患者而/ 3 tc /一步法治疗一段时间的9个月跟进。使用重复的病例对照研究措施,连续测量模型使用。酒精-使用生物标记被用来规范酒精使用的性别差异。共有41名患者筛查慢性饮酒的审计工具。21例患者进入对照组没有慢性酒精用户和其他20例慢性酒精使用根据世界卫生组织的审计工具的分数。自工具不够敏感的患者对照组又解决使用慢性酒精使用生物标记。两项研究与世卫组织审计工具组和慢性酒精使用生物标记。两组随访9个月的血液抽样每隔3个月完成。 The immune blood cells (WBC count and differential counts) were determined using automated hematological Coulter CBC-5 Hematology Analyzer. Results were then sorted by alcohol-use biomarkers since WHO AUDIT tool was not sensitive enough to screen patients. Mean WBC counts were slightly higher at baseline and 3 month in chronic alcohol use group as compared to controls. There was variation in differential counts at different time intervals between control and chronic alcohol use for both alcohol-use biomarkers and WHO AUDIT tool groups. Generally, differential counts slightly varied between chronic alcohol use and the control groups but it was statistically insignificant (pï€ ï‚³0.05) between the 2 groups. Chronic alcohol use by HIV/AIDS patients on d4T/ 3TC/NVP regimen reduced the mean WBC count, % lymphocytes, % monocytes and % basophils in both WHO AUDIT tool and alcohol-use biomarkers group.