文摘

抗菌和抗真菌的活动N-Lactosides一些小说

作者(年代):p . t . Agrawal y . a .艾莉雅和s·p·德斯穆克

A series of N-lactosides like 1-hepta-O-benzoyl--D-lactosyl-3-aryl thiocarbamides, thiocarbamates and benzothiazolyl thiocarbamides were synthesized by the interaction of 1-hepta-Obenzoyl- -D-lactosyl isothiocyanate with aryl amines, alcohols and 2-amino benzothiazole / substituted benzothiazoles, respectively. 1-Aryl-5-hepta-O-benzoyl--D-lactosyl-2-S-benzyl-2, 4-isoditiobiurets were synthesized by the interaction of 1-hepta-O-benzoyl--D-lactosyl isothiocyanate with S-benzyl-aryl isothiocarbamides. 3 – Hepta – O - benzoyl – 6 - D - lactosylimino - 5- arylimino - 1, 2, 4 - dithiazolidines (hydrobromide) were synthesized by oxidative debenzylation and cyclization of 1-aryl-5- hepta-O-benzoyl--D-lactosyl-2-S-benzyl-2, 4-isodithiobiurets with molecular bromine in chloroform medium. These newly synthesized compounds were characterized on the basis of usual chemical transformations, IR,核磁共振和质谱分析。在目前的调查,这些活动对致病性Nlactosides baceteria和真菌如大肠杆菌,金黄色葡萄球菌,p .寻常的伤寒杆菌、念珠菌guilliermondii和a .尼日尔进行了讨论。