文摘

多样性和药敏分析概要酵母分离及其生物膜的生产特点在艾滋病毒和艾滋病与结核病患者

作者(年代):注意:Okelo, J.K.Toure

尽管一些真菌生物已知感染艾滋病毒和艾滋病患者,酵母病原体感染个体的多样性在肯尼亚是未知的。在目前研究sputumsampleswere fromHIV积极收集与结核病患者在医院。酵母生物被germtube孤立使用土豆DextroseAgar和确认测试,CHROMagar和基于脲酶的琼脂。生物膜的生产测试使用microtitre板的方法。两性霉素B的活性、氟康唑和Ketaconazole使用标准纸片扩散法进行了测试。91名患者,53例(58%)是女性。三十7例(41%)年龄在26岁至45岁。最常见的isolateswere新型隐球菌(28%),随后byCndida parapsilopsis (19%), c . krusei(16%)、白念珠菌(15%)和c . tropicalis (13%)。不同物种显示高水平的药物氟康唑(74.0%)、阻力ketaconazole(74.0%)和两性霉素B (33.7%)。生物膜生产中观察到28%的隔离,也与耐药相关(p > 0.01)。 This study shows that the lungs of HIV patients with TB are often colonized by opportunistic yeasts such as Cryptococcus and Candida spp. The most common isolates included Cryptococcus neoformans, Candida parapsiliosis, Candida krusei and Candida albicans, and amphotericin B was the most active drug against these organisms. Further studies are needed to determine the potential impact of these organisms on the emergence ofmulti-drug resistant (MDR) and extensively drug resistant tuberculosis (XDR TB).