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1,3-二硫代羰基苯基二肼的大环席夫碱

罗纳德·渡轮^＊

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罗纳德·渡轮
印度有机化学杂志编辑部
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摘要

电化学测试用于评估这些化合物在1M H2 SO4中防止低碳钢腐蚀的能力。研究了新型大环腙席夫碱对革兰氏阳性杆菌(枯草芽孢杆菌和金黄色葡萄球菌)和革兰氏阴性杆菌(枯草芽孢杆菌和金黄色葡萄球菌)的抑菌性能。微生物(伤寒沙门氏菌和大肠杆菌)。化学配体对细菌生长的抑制作用是可变的。

简介

由于各种原因，希夫碱在自然结合和金属颗粒配合物领域得到了广泛的研究和应用:它们在生理和药理学上的应用，在粒子特定阴极中，在生态例子中重金属颗粒的保证，在金属颗粒的提取及其众多的反应物应用中，如烯烃的环氧化，烯烃的环丙化，酮的三甲基硅基氰化，hilter kilter甲基苯基硫化物的氧化，硅基诺的对映选择性环氧化和丙交酯的开环聚合。腙是希夫碱家族中混合物的非凡聚集物。它们由(C=NN=C)的存在来描述。酰基、芳基和异丙基化合物的席夫碱都有额外的供体，如C=O。额外的给予者地点使他们更具适应性和灵活性。这种适应性使水合物成为多齿螯合的专家，可以用不同的进展和内部变化金属塑造各种各样的建筑物，当然也会从众多分析师中脱颖而出。根据试验条件获得不同的腙;它们可以作为有机动态混合物和逻辑试剂。作为天然的动态混合物，腙在抗生长、结核病、感染和精神疾病等疾病的治疗中得到应用。 For Tuberculostatic action is ascribed to the development of stable chelates with change metals present in the cell. Accordingly numerous imperative enzymatic responses catalyzed by these change metals can't happen within the sight of hydrazones. Hydrazones likewise go about as herbicides, insect sprays, nematicides, rodenticides, plant development controllers development controllers. Every one of the synthetic substances utilized were of Analytical grade and obtained from Sigma-Aldrich and Fluka. Metal salts were bought from E. Merckand were utilized as gotten. The components C, H, and N were broke down ona Carlo-Erba 1106 natural analyzer. The IR spectra were recorded on Jusco 300 instrument in KBr pellets. 1 H核磁共振在布鲁克DT-400 MHz光谱仪上记录CDCl3排列的配体光谱，物质位移以ppm计算。采用KRATOS MS50TC谱仪记录质谱。采用AA 929 Unicam光谱仪进行空气乙炔火火焰原子吸收光谱(FAAS)测定。同样使用了pH计(Metrohm - 691 pH计)。所有的萃取试验都是在50立方厘米的带塞玻璃壶中使用机械玻璃瓶启动器进行的，M.P数码仪器(32- 300°C)。利用Amel仪器的恒钾恒流器进行消耗运动。异眼酸(1.66 gm, 0.1 mmol)稀释于超干甲醇(60 mL)中，含2-3滴浓缩H2 SO4 (AR)。然后将活性混合物放入冰水中，固体几乎很快就开始从透明溶液中分离出来。向其中加入碳酸氢钠溶液，直到气泡停止。然后将酯过滤并用水冲洗多次(MP: 64 - 67°C)。 The pre-arranged mixtures were tried for their antimicrobial movement against four types of microscopic organisms (Bacillus subtilis, Escherichiacoli, Staphylococcus aureus, Salmonella typhi) utilizing channel paper plate technique. The screened compounds were broken down independently in DMSO (dimethyl sulfoxide) to make up an answer of 50, 100, and 200 μg/ml fixation for every one of these mixtures. Channel paper circles (Whatman No.1 channel paper, 5 mm width) were immersed with the arrangement of these mixtures. The circles were put on the outer layer of hardened Nutrient agar dishes cultivated by the tried microbes. The breadths of restraint zones (mm) were estimated toward the finish of a hatching period, which was 24 hours at 37ºC for microscopic organisms. Plates are soaked with DMSO are utilized as dissolvable control. Ciprofloxacin 100 μg/ml was utilized as reference substance for microscopic organisms. The arranged macrocyclic hydrazone (VIII, IX, X, XI) were integrated by buildup of transitional mixtures: 1,6-bis(2-formylphenel) hexane,1,6-bis (2-acetyl-phenyl) hexane(V), α,α'- bis(2-carboxyaldehyde phenoxy) xylene(VI), and 1,7-bis (2- formyl-phenyl)- 1,4,7-trioxaheptane(VII) with 1,3-Dithiocarbohydrazide(III) in the molar proportion (2:2) in DMF. The responses continued without a hitch, creating the relating Schiff bases ligands in great yield. The ligands are dissolvable in like manner natural dissolvable yet insoluble in water. The designs of the ligands were clarified by essential examinations, MS, FTIR, electronic ingestion, and 1 H-NMR spectra, which help in explaining their observational equation. The change of metal/arrangement interface from a condition of dynamic disintegration to the detached state is credited to the adsorption of the inhibitor particles and the metal surface, framing a defensive film. The pace of adsorption is generally quick and thus, the receptive metal surface is safeguarded from the forceful climate, Adsorption interaction can happen by electrostatic powers between ionic charges or dipoles of the adsorbed物种(确定带电的质子化氮粒子与相反带电的温和钢表面(阴极目的地)之间的静电魅力)与金属表面的电荷在零电荷势方面可以通过其真实容量进行交流，也可以吸附抑制剂原子物种的空电子轨道低能源在金属上形成某种方向的连接。抑制剂原子的吸附通常是一种排出反应，包括吸附水粒子的排出，通常是一种拔除反应，包括从金属表面排出吸附水原子。研究不同新型席夫碱的混合物是合理的，并集中研究它们对四种微生物(枯草芽孢杆菌、大肠杆菌、金黄色葡萄球菌和伤寒沙门氏菌)的抗菌运动。所筛选化合物的固定浓度分别为50、100和200 μg/ml。以环丙沙星为参考标准，DMSO为控制区和抑制区，以毫米为单位。新混合物分别对一个革兰氏阳性菌株和两个革兰氏阴性菌株进行试验。另一种化合物是动态的，另一种化合物不是动态的。

结论

这些混合物是新的，而且很有趣。通过软化点、HNMR、IR、LC-MS等基本检查，对新混合物进行了鉴别。预先安排的混合物已经过有机筛选，即集中其所属物以抵御两种革兰氏阳性和两种革兰氏阴性微生物。结果显示，他们的运动量从中等到非常惊人。结果，显然，这四种化合物都集中在加强工作作为成功的侵蚀抑制剂在1M H2 SO2介质中，化合物(VIII, IX)是四种混合物中最出色的。